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The Poppi trial is a single centre randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants. In this trial, we explored whether morphine analgesia reduced clinical pain scores following retinopathy of prematurity (ROP) screening. We also investigated the the effect of morphine on electrophysiological measures of nociceptive brain and spinal cord activity evoked by a heel lance. Infants were randomised to receive either morphine or a placebo prior to a clinically required heel lance and ROP screen, which were performed on the same test occasion. The effect of morphine on clinical pain scores (evoked by the heel lance and ROP screening), nociceptive-specific brain activity and spinal cord activity (evoked by clinical heel lance), clinical stability, and drug safety were investigated.

The trial was led by Prof Rebeccah Slater and Dr Eleri Adams, and conducted in collaboration with the National Perinatal Epidemiology Unit (NPEU). The trial has now stopped recruitment, and the results will be published shortly. More information about the Poppi trial is available on the NPEU Poppi website. 

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