Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The Poppi trial is a single centre randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants. Infants were randomised to receive either morphine or a placebo prior to a clinically required heel lance and ROP screen, which were performed on the same test occasion. The effect of morphine on clinical pain scores (evoked by the heel lance and ROP screening), nociceptive-specific brain activity and spinal cord activity (evoked by clinical heel lance), clinical stability, and drug safety were investigated.

The trial was led by Prof Rebeccah Slater and Dr Eleri Adams and conducted in collaboration with the National Perinatal Epidemiology Unit (NPEU). The results of the trial and other related publications can be found here:

 

-           Protocol

-           Main trial results

-           Full report of the trial

-           Post-hoc analysis of trial data investigating whether adverse cardiorespiratory effects of morphine can be predicted from an individual infant’s vital signs prior to drug administration

Browse projects

Related research themes