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The Poppi trial is a single centre randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants. Infants were randomised to receive either morphine or a placebo prior to a clinically required heel lance and ROP screen, which were performed on the same test occasion. The effect of morphine on clinical pain scores (evoked by the heel lance and ROP screening), nociceptive-specific brain activity and spinal cord activity (evoked by clinical heel lance), clinical stability, and drug safety were investigated.

The trial was led by Prof Rebeccah Slater and Dr Eleri Adams and conducted in collaboration with the National Perinatal Epidemiology Unit (NPEU). The results of the trial and other related publications can be found here:


-           Protocol

-           Main trial results

-           Full report of the trial

-           Post-hoc analysis of trial data investigating whether adverse cardiorespiratory effects of morphine can be predicted from an individual infant’s vital signs prior to drug administration

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