We conduct randomised controlled trials to investigate the efficacy and safety of analgesics in infants.
Analgesics are frequently not provided for infants undergoing painful medically-required procedures due to the difficulty in assessing whether they are effective, and concerns around side effects. Early life pain is associated with both short and long-term effects, including associations with lower cognitive ability. It is essential that we find better ways to treat pain to mitigate the short and long-term effects. We use a variety of different approaches (such as examining brain activity responses, behavioural changes, and physiological responses) to gain a full understanding of how analgesics affect infant responses to painful procedures and to establish the safety of the drugs.