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Our research

Our research focuses on human neonatal brain development. We undertake mechanistic research, clinical trials, methodology development (MRI, EEG and analytical approaches), with a particular focus on infant pain.

Themes
Projects

Analysis Methods

Analysis Methods

We conduct randomised controlled trials to investigate the efficacy and safety of analgesics in infants.

Clinical Trials

We use MRI and EEG to investigate how the human brain changes in early development.

Human Brain Development

Identifying when infants are in pain is challenging as they cannot tell us their experiences. We investigate how the brain responds to noxious stimuli to find better ways to measure and treat infant pain.

Infant Pain

Does gentle touch reduce infant pain-related brain activity?

Does gentle touch reduce infant pain-related brain activity?

We will obtain high resolution postmortem imaging data of the infant brain. This project is part of the developing Human Connectome Project and aims to improve our understanding of the structural and functional development of the human infant brain.

Forget-Me-Not - postmortem MRI

How do surgical procedures affect infant pain-related brain activity?

How do surgical procedures affect infant pain-related brain activity?

How does behavioural pain discrimination develop in early life?

How does behavioural pain discrimination develop in early life?

How does brain injury alter sensory processing in newborn infants?

How does brain injury alter sensory processing in newborn infants?

How does early life experience modulate the development of sensory function in human infants?

How does early life experience modulate the development of sensory function in human infants?

How does early life infection impact pain perception in infants?

How does early life infection impact pain perception in infants?

Identifying brain signatures and physiological markers of infant pain.

Identifying brain signatures and physiological markers of infant pain.

Is the descending pain modulatory system effective in newborn infants?

Is the descending pain modulatory system effective in newborn infants?

Developing next generation magnetoencephalography for children

MEG imaging in young children

Optimising Neonatal fMRI Data Analysis for noxious-evoked brain activity.

Optimising Neonatal fMRI Data Analysis for noxious-evoked brain activity.

Poppi: Procedural Pain in Premature Infants

Poppi: Procedural Pain in Premature Infants